Genetic Fact Sheets for Parents

Fatty Acid Oxidation Disorders

Print Version

Disorder Name:   Carnitine palmitoyl transferase, type 1A arctic variant
Acronym:              CPT1A arctic variant

CPT1A ARCTIC VARIANT – INHERITANCE PATTERNS

If both parents have one copy of the CPT1A arctic variant gene and one copy of the wild type CPT1A gene, they are called carriers. If this couple has children, 25% will have two copies with the arctic variant, 25% will have no copies of the arctic variant, and half (50%) will have one copy with the arctic variant. See diagram below.

CPT1A Arctic Variant Carrier Carrier

If both parents have two copies of the CPT1A arctic variant gene, then they both have CPT1A arctic variant. All of their children will also have two copies of the CPT1A arctic variant gene. See diagram below.

CPT1A Arctic Variant Both Condition

If one parent has two copies of the CPT1A arctic variant gene (has CPT1A arctic variant) and the other parent has only one copy of the CPT1A arctic variant gene (arctic variant carrier), then half of their children (50%) will have two copies of the CPT1A arctic variant gene, and the other half will have only one copy of the CPT1A arctic variant gene (arctic variant carriers). See diagram below.

CPT1A Arctic Variant Carrier Condition

If one parent has two copies of the CPT1A arctic variant gene (has CPT1A arctic variant) and the other parent has no of the CPT1A arctic variant gene (has wild type), then all of their children (100%) will have one copy with the arctic variant (arctic variant carriers). See diagram below.

CPT1A Arctic Varant Condition Normal

If one parent has no copies of the CPT1A arctic variant gene (has wild type) and the other parent has one copy of the CPT1A arctic variant gene (arctic variant carrier), then 50% of their children will have one copy of the CPT1A arctic variant gene (arctic variant carriers) and 50% will have no copies (wild type). See diagram below.

CPT1A Arctic Variant Normal Carrier

If neither parent has a copy of the CPT1A gene with the arctic variant (both have wild type), then none of their children will have it either (all children will be wild type). No diagram provided.

  Print Version

DISCLAIMER:

THIS INFORMATION DOES NOT PROVIDE MEDICAL ADVICE. All content ("Content"), including text, graphics, images and information are for general informational purposes only. You are encouraged to confer with your doctor or other health care professional with regard to information contained on this information sheet. After reading this information sheet, you are encouraged to review the information carefully with your doctor or other healthcare provider. The Content is not intended to be a substitute for professional medical advice, diagnosis or treatment. NEVER DISREGARD PROFESSIONAL MEDICAL ADVICE, OR DELAY IN SEEKING IT, BECAUSE OF SOMETHING YOU HAVE READ ON THIS INFORMATION SHEET. This project is supported by a grant from the Maternal and Child Health Bureau, Health Resources and Service Administration, Genetic Services Branch, MCH Project #:1H46 MC 00189-03 http://mchb.hrsa.gov

Fact Sheet was last updated on: 12/18/14